Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion
Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Three genes are known to be essential for gamete adhesion/fusion (
Cd9, Izumo1
and
Juno
). Here, we confirmed that
Spaca6
null males are infertile and showed that their sperm accumulate in the perivitelline space but are unable to fuse with oocyte. Like IZUMO1, SPACA6 which is expressed by human sperm, is remained on the equatoria...
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Full title
Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7093486
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7093486
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-62091-y
