The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Although the malfunction of HtrA2/Omi leads to Parkinson’s disease (PD), the underlying mechanism has remained unknown. Here, we showed that HtrA2/Omi specifically removed oligomeric α-Syn but not monomeric α-Syn to protect oligomeric α-Syn-induced neurodegeneration. Experiments using mnd2 mice indicated that HtrA2/Omi degraded oligomeric α-Syn spe...
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The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7093540
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7093540
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-62309-z
