Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Ubiquitin is a highly conserved 76 amino-acid protein that covalently attaches to protein substrates targeted for degradation by the 26S proteasome. The coordinated effort of a series of enzymes, including an activating enzyme (E1), a conjugating enzyme (E2) and a ligase (E3), uses ATP to ultimately form an isopeptide bond between ubi...
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Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7097807
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7097807
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd3321
