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An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

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An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7108171

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

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London: Nature Publishing Group UK

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Contents

Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour types and with the response to immunotherapy
1
–
8
. However, the reason some tumours have high CD8 T cell infiltration while others do not remains unclear. Here we investigate the requirements for maintaining a CD8 T cell response against human can...

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Full title

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7108171

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7108171

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-019-1836-5

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