Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
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Author / Creator
Xie, Yadong , Zhao, Yifan , Shi, Lei , Li, Wei , Chen, Kun , Li, Min , Chen, Xia , Zhang, Haiwei , Li, Tiantian , Matsuzawa-Ishimoto, Yu , Yao, Xiaomin , Shao, Dianhui , Ke, Zunfu , Li, Jian , Chen, Yan , Zhang, Xiaoming , Cui, Jun , Cui, Shuzhong , Leng, Qibin , Cadwell, Ken , Li, Xiaoxia , Wei, Hong , Zhang, Haibing , Li, Huabin and Xiao, Hui
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Although Western diet and dysbiosis are the most prominent environmental factors associated with inflammatory bowel diseases (IBDs), the corresponding host factors and cellular mechanisms remain poorly defined. Here we report that the TSC1/mTOR pathway in the gut epithelium represents a metabolic and innate immune checkpoint for intestinal dysfunct...
Alternative Titles
Full title
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7108921
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7108921
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI133264
