Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolys...
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
About this item
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Author / Creator
Weisel, Florian J. , Mullett, Steven J. , Elsner, Rebecca A. , Menk, Ashley V. , Trivedi, Nikita , Luo, Wei , Wikenheiser, Daniel , Hawse, William F. , Chikina, Maria , Smita, Shuchi , Conter, Laura J. , Joachim, Stephen M. , Wendell, Stacy G. , Jurczak, Michael J. , Winkler, Thomas H. , Delgoffe, Greg M. and Shlomchik, Mark J.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are exceptional among proliferating B and T cells,...
Alternative Titles
Full title
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7112716
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7112716
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0598-4
