A thermostable, closed SARS-CoV-2 spike protein trimer
A thermostable, closed SARS-CoV-2 spike protein trimer
About this item
Full title
Author / Creator
Xiong, Xiaoli , Qu, Kun , Ciazynska, Katarzyna A. , Hosmillo, Myra , Carter, Andrew P. , Ebrahimi, Soraya , Ke, Zunlong , Scheres, Sjors H. W. , Bergamaschi, Laura , Grice, Guinevere L. , Zhang, Ying , Nathan, James A. , Baker, Stephen , James, Leo C. , Baxendale, Helen E. , Goodfellow, Ian , Doffinger, Rainer , Briggs, John A. G. , CITIID-NIHR COVID-19 BioResource Collaboration and The CITIID-NIHR COVID-19 BioResource Collaboration
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. It exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose its receptor-binding site and, subsequently, from prefusion to postfusion conformations to mediate fusion of vira...
Alternative Titles
Full title
A thermostable, closed SARS-CoV-2 spike protein trimer
Authors, Artists and Contributors
Author / Creator
Qu, Kun
Ciazynska, Katarzyna A.
Hosmillo, Myra
Carter, Andrew P.
Ebrahimi, Soraya
Ke, Zunlong
Scheres, Sjors H. W.
Bergamaschi, Laura
Grice, Guinevere L.
Zhang, Ying
Nathan, James A.
Baker, Stephen
James, Leo C.
Baxendale, Helen E.
Goodfellow, Ian
Doffinger, Rainer
Briggs, John A. G.
CITIID-NIHR COVID-19 BioResource Collaboration
The CITIID-NIHR COVID-19 BioResource Collaboration
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116388
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116388
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-0478-5
