Age-related myelin degradation burdens the clearance function of microglia during aging
Age-related myelin degradation burdens the clearance function of microglia during aging
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Safaiyan
et al
. demonstrate that myelin fragments progressively pinch off from aged myelin sheaths and are taken up and cleared by microglia. Age-associated myelin breakdown is substantial and saturates the degradative capacities of microglia, leading to lysosomal storage and an immune activation in microglia with time.
Myelin is synthesi...
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Full title
Age-related myelin degradation burdens the clearance function of microglia during aging
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116794
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116794
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4325
