Opposing T cell responses in experimental autoimmune encephalomyelitis
Opposing T cell responses in experimental autoimmune encephalomyelitis
About this item
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Author / Creator
Saligrama, Naresha , Zhao, Fan , Sikora, Michael J. , Serratelli, William S. , Fernandes, Ricardo A. , Louis, David M. , Yao, Winnie , Ji, Xuhuai , Idoyaga, Juliana , Mahajan, Vinit B. , Steinmetz, Lars M. , Chien, Yueh-Hsiu , Hauser, Stephen L. , Oksenberg, Jorge R. , Garcia, K. Christopher and Davis, Mark M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4
+
, CD8
+
and γδ
+
T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find major expansions of CD8<...
Alternative Titles
Full title
Opposing T cell responses in experimental autoimmune encephalomyelitis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7145319
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7145319
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1467-x
