Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central ner...
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
About this item
Full title
Author / Creator
Rawji, Khalil S. , Young, Adam M.H. , Ghosh, Tanay , Michaels, Nathan J. , Mirzaei, Reza , Kappen, Janson , Kolehmainen, Kathleen L. , Alaeiilkhchi, Nima , Lozinski, Brian , Mishra, Manoj K. , Pu, Annie , Tang, Weiwen , Zein, Salma , Kaushik, Deepak K. , Keough, Michael B. , Plemel, Jason R. , Calvert, Fiona , Knights, Andrew J. , Gaffney, Daniel J. , Tetzlaff, Wolfram , Franklin, Robin J. M. and Yong, V. Wee
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contribute to this decline. Microglia and monocyte-deriv...
Alternative Titles
Full title
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
Authors, Artists and Contributors
Author / Creator
Young, Adam M.H.
Ghosh, Tanay
Michaels, Nathan J.
Mirzaei, Reza
Kappen, Janson
Kolehmainen, Kathleen L.
Alaeiilkhchi, Nima
Lozinski, Brian
Mishra, Manoj K.
Pu, Annie
Tang, Weiwen
Zein, Salma
Kaushik, Deepak K.
Keough, Michael B.
Plemel, Jason R.
Calvert, Fiona
Knights, Andrew J.
Gaffney, Daniel J.
Tetzlaff, Wolfram
Franklin, Robin J. M.
Yong, V. Wee
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7181452
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7181452
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-020-02129-7
