Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type...
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
About this item
Full title
Author / Creator
Abdelsamed, Hossam A. , Zebley, Caitlin C. , Nguyen, Hai , Rutishauser, Rachel L. , Fan, Yiping , Ghoneim, Hazem E. , Crawford, Jeremy Chase , Alfei, Francesca , Alli, Shanta , Ribeiro, Susan Pereira , Castellaw, Ashley H. , McGargill, Maureen A. , Jin, Hongjian , Boi, Shannon K. , Speake, Cate , Serti, Elisavet , Turka, Laurence A. , Busch, Michael E. , Stone, Mars , Deeks, Steven G. , Sekaly, Rafick-Pierre , Zehn, Dietmar , James, Eddie A. , Nepom, Gerald T. and Youngblood, Ben
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The pool of beta cell-specific CD8
+
T cells in type 1 diabetes (T1D) sustains an autoreactive potential despite having access to a constant source of antigen. To investigate the long-lived nature of these cells, we established a DNA methylation-based T cell ‘multipotency index’ and found that beta cell-specific CD8
+
T cells retained a...
Alternative Titles
Full title
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
Authors, Artists and Contributors
Author / Creator
Zebley, Caitlin C.
Nguyen, Hai
Rutishauser, Rachel L.
Fan, Yiping
Ghoneim, Hazem E.
Crawford, Jeremy Chase
Alfei, Francesca
Alli, Shanta
Ribeiro, Susan Pereira
Castellaw, Ashley H.
McGargill, Maureen A.
Jin, Hongjian
Boi, Shannon K.
Speake, Cate
Serti, Elisavet
Turka, Laurence A.
Busch, Michael E.
Stone, Mars
Deeks, Steven G.
Sekaly, Rafick-Pierre
Zehn, Dietmar
James, Eddie A.
Nepom, Gerald T.
Youngblood, Ben
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7183435
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7183435
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0633-5
