Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα-mediated lipid metabolism
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα-mediated lipid metabolism
About this item
Full title
Author / Creator
Zhou, Xin , He, Chenxi , Ren, Jiangong , Dai, Congxin , Stevens, Sharon R , Wang, Qianghu , Zamler, Daniel , Shingu, Takashi , Yuan, Liang , Chandregowda, Chythra R , Wang, Yunfei , Ravikumar, Visweswaran , Rao, Arvind Uk , Zhou, Feng , Zheng, Hongwu , Rasband, Matthew N , Chen, Yiwen , Lan, Fei , Heimberger, Amy B , Segal, Benjamin M and Hu, Jian
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specif...
Alternative Titles
Full title
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα-mediated lipid metabolism
Authors, Artists and Contributors
Author / Creator
He, Chenxi
Ren, Jiangong
Dai, Congxin
Stevens, Sharon R
Wang, Qianghu
Zamler, Daniel
Shingu, Takashi
Yuan, Liang
Chandregowda, Chythra R
Wang, Yunfei
Ravikumar, Visweswaran
Rao, Arvind Uk
Zhou, Feng
Zheng, Hongwu
Rasband, Matthew N
Chen, Yiwen
Lan, Fei
Heimberger, Amy B
Segal, Benjamin M
Hu, Jian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7191000
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7191000
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI131800
