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Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after isc...

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after isc...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7196296

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

About this item

Full title

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

Publisher

Australia: Ivyspring International Publisher Pty Ltd

Journal title

Theranostics, 2020-01, Vol.10 (12), p.5341-5356

Language

English

Formats

Publication information

Publisher

Australia: Ivyspring International Publisher Pty Ltd

More information

Scope and Contents

Contents

Acute ischemic stroke treatment faces an unresolved obstacle as capillary reperfusion remains insufficient after thrombolysis and thrombectomy causing neuronal damage and poor prognosis. Hypoxia-induced capillary constriction is mediated by actomyosin contraction in precapillary smooth muscle cells (SMCs) therefore smooth muscle myosin-2 could be a...

Alternative Titles

Full title

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7196296

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7196296

Other Identifiers

ISSN

1838-7640

E-ISSN

1838-7640

DOI

10.7150/thno.42077

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