Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation
Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
An ER transmembrane protein, vesicle-associated membrane protein-associated protein B (VAPB), binds to several organelle-resident membrane proteins to mediate ER-organelle tethering. Mutation in amyotrophic lateral sclerosis (ALS) induces protein misfolding and aggregation, leading to ER disorganization. Gain or loss of function is suggested for VA...
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Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7203144
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7203144
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-64517-z
