Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
About this item
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Author / Creator
Lu, Linlin , Chen, Zhuojia , Lin, Xinyao , Tian, Lin , Su, Qiao , An, Panpan , Li, Wuguo , Wu, Yingmin , Du, Jun , Shan, Hong , Chiang, Cheng-Ming and Wang, Hongsheng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
The mechanistic action of bromodomain-containing protein 4 (BRD4) in cancer motility, including epithelial-mesenchymal transition (EMT), remains largely undefined. We found that targeted inhibition of BRD4 reduces migration, invasion, in vivo growth of patient-derived xenograft (PDX), and lung colonization of breast cancer (BC) cells. Inhibition of...
Alternative Titles
Full title
Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7205888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7205888
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-019-0353-2
