PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mi...
PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
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Author / Creator
Alzheimer’s Disease Neuroimaging Initiative (ADNI) , Kleineidam, Luca , Chouraki, Vincent , Próchnicki, Tomasz , van der Lee, Sven J. , Madrid-Márquez, Laura , Wagner-Thelen, Holger , Karaca, Ilker , Weinhold, Leonie , Wolfsgruber, Steffen , Boland, Anne , Martino Adami, Pamela V. , Lewczuk, Piotr , Popp, Julius , Brosseron, Frederic , Jansen, Iris E. , Hulsman, Marc , Kornhuber, Johannes , Peters, Oliver , Berr, Claudine , Heun, Reinhard , Frölich, Lutz , Tzourio, Christophe , Dartigues, Jean-François , Hüll, Michael , Espinosa, Ana , Hernández, Isabel , de Rojas, Itziar , Orellana, Adelina , Valero, Sergi , Stringa, Najada , van Schoor, Natasja M. , Huisman, Martijn , Scheltens, Philip , Rüther, Eckart , Deleuze, Jean-Francois , Wiltfang, Jens , Tarraga, Lluis , Schmid, Matthias , Scherer, Martin , Riedel-Heller, Steffi , Heneka, Michael T. , Amouyel, Philippe , Jessen, Frank , Boada, Merce , Maier, Wolfgang , Schneider, Anja , González-Pérez, Antonio , van der Flier, Wiesje M. , Wagner, Michael , Lambert, Jean-Charles , Holstege, Henne , Sáez, Mª Eugenia , Latz, Eicke , Ruiz, Agustin and Ramirez, Alfredo
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
A rare coding variant (rs72824905, p.P522R) conferring protection against Alzheimer’s disease (AD) was identified in the gene encoding the enzyme phospholipase-C-γ2 (
PLCG2
) that is highly expressed in microglia. To explore the protective nature of this variant, we employed latent process linear mixed models to examine the association of p.P...
Alternative Titles
Full title
PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
Authors, Artists and Contributors
Author / Creator
Kleineidam, Luca
Chouraki, Vincent
Próchnicki, Tomasz
van der Lee, Sven J.
Madrid-Márquez, Laura
Wagner-Thelen, Holger
Karaca, Ilker
Weinhold, Leonie
Wolfsgruber, Steffen
Boland, Anne
Martino Adami, Pamela V.
Lewczuk, Piotr
Popp, Julius
Brosseron, Frederic
Jansen, Iris E.
Hulsman, Marc
Kornhuber, Johannes
Peters, Oliver
Berr, Claudine
Heun, Reinhard
Frölich, Lutz
Tzourio, Christophe
Dartigues, Jean-François
Hüll, Michael
Espinosa, Ana
Hernández, Isabel
de Rojas, Itziar
Orellana, Adelina
Valero, Sergi
Stringa, Najada
van Schoor, Natasja M.
Huisman, Martijn
Scheltens, Philip
Rüther, Eckart
Deleuze, Jean-Francois
Wiltfang, Jens
Tarraga, Lluis
Schmid, Matthias
Scherer, Martin
Riedel-Heller, Steffi
Heneka, Michael T.
Amouyel, Philippe
Jessen, Frank
Boada, Merce
Maier, Wolfgang
Schneider, Anja
González-Pérez, Antonio
van der Flier, Wiesje M.
Wagner, Michael
Lambert, Jean-Charles
Holstege, Henne
Sáez, Mª Eugenia
Latz, Eicke
Ruiz, Agustin
Ramirez, Alfredo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7244617
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7244617
Other Identifiers
ISSN
0001-6322,1432-0533
E-ISSN
1432-0533
DOI
10.1007/s00401-020-02138-6
