Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling
Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling
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Publisher
Switzerland: MDPI
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Language
English
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Publisher
Switzerland: MDPI
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Scope and Contents
Contents
T cell activation is initiated when ligand binding to the T cell receptor (TCR) triggers intracellular phosphorylation of the TCR-CD3 complex. However, it remains unknown how biophysical properties of TCR engagement result in biochemical phosphorylation events. Here, we constructed an optogenetic tool that induces spatial clustering of ζ-chain in a...
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Full title
Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling
Authors, Artists and Contributors
Author / Creator
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7279048
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7279048
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ISSN
1422-0067
E-ISSN
1422-0067
DOI
10.3390/ijms21103498
