Translational reprogramming marks adaptation to asparagine restriction in cancer
Translational reprogramming marks adaptation to asparagine restriction in cancer
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
While amino acid restriction remains an attractive strategy for cancer therapy, metabolic adaptations limit its effectiveness. Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. Asparagine limitation in melanoma and pancreatic cancer cells activates receptor tyrosine kinase–MAPK signalli...
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Full title
Translational reprogramming marks adaptation to asparagine restriction in cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7307327
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7307327
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-019-0415-1
