A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly...
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
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Author / Creator
Dominantly Inherited Alzheimer Network , the Dominantly Inherited Alzheimer Network , Barthélemy, Nicolas R. , Li, Yan , Joseph-Mathurin, Nelly , Gordon, Brian A. , Hassenstab, Jason , Benzinger, Tammie. L. S. , Buckles, Virginia , Fagan, Anne M. , Perrin, Richard J. , Goate, Alison M. , Morris, John C. , Karch, Celeste M. , Xiong, Chengjie , Allegri, Ricardo , Mendez, Patricio Chrem , Berman, Sarah B. , Ikeuchi, Takeshi , Mori, Hiroshi , Shimada, Hiroyuki , Shoji, Mikio , Suzuki, Kazushi , Noble, James , Farlow, Martin , Chhatwal, Jasmeer , Graff-Radford, Neill R. , Salloway, Stephen , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , O’Connor, Antoinette , Fox, Nick C. , Levin, Johannes , Jucker, Mathias , Gabelle, Audrey , Lehmann, Sylvain , Sato, Chihiro , Bateman, Randall J. and McDade, Eric
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four decades of disease progression in dominantly inherited Alzheimer’s disease. We identified a patt...
Alternative Titles
Full title
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
Authors, Artists and Contributors
Author / Creator
the Dominantly Inherited Alzheimer Network
Barthélemy, Nicolas R.
Li, Yan
Joseph-Mathurin, Nelly
Gordon, Brian A.
Hassenstab, Jason
Benzinger, Tammie. L. S.
Buckles, Virginia
Fagan, Anne M.
Perrin, Richard J.
Goate, Alison M.
Morris, John C.
Karch, Celeste M.
Xiong, Chengjie
Allegri, Ricardo
Mendez, Patricio Chrem
Berman, Sarah B.
Ikeuchi, Takeshi
Mori, Hiroshi
Shimada, Hiroyuki
Shoji, Mikio
Suzuki, Kazushi
Noble, James
Farlow, Martin
Chhatwal, Jasmeer
Graff-Radford, Neill R.
Salloway, Stephen
Schofield, Peter R.
Masters, Colin L.
Martins, Ralph N.
O’Connor, Antoinette
Fox, Nick C.
Levin, Johannes
Jucker, Mathias
Gabelle, Audrey
Lehmann, Sylvain
Sato, Chihiro
Bateman, Randall J.
McDade, Eric
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7309367
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7309367
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X,1744-7933
DOI
10.1038/s41591-020-0781-z
