Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated chang...
Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties
About this item
Full title
Author / Creator
Panciera, Tito , Citron, Anna , Di Biagio, Daniele , Battilana, Giusy , Gandin, Alessandro , Giulitti, Stefano , Forcato, Mattia , Bicciato, Silvio , Panzetta, Valeria , Fusco, Sabato , Azzolin, Luca , Totaro, Antonio , Dei Tos, Angelo Paolo , Fassan, Matteo , Vindigni, Vincenzo , Bassetto, Franco , Rosato, Antonio , Brusatin, Giovanna , Cordenonsi, Michelangelo and Piccolo, Stefano
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Defining the interplay between the genetic events and microenvironmental contexts necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology. We found that receptor tyrosine kinase (RTK)–Ras oncogenes reprogram normal, freshly explanted primary mouse and human cells into tumour precursors, in a process requiring in...
Alternative Titles
Full title
Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties
Authors, Artists and Contributors
Author / Creator
Citron, Anna
Di Biagio, Daniele
Battilana, Giusy
Gandin, Alessandro
Giulitti, Stefano
Forcato, Mattia
Bicciato, Silvio
Panzetta, Valeria
Fusco, Sabato
Azzolin, Luca
Totaro, Antonio
Dei Tos, Angelo Paolo
Fassan, Matteo
Vindigni, Vincenzo
Bassetto, Franco
Rosato, Antonio
Brusatin, Giovanna
Cordenonsi, Michelangelo
Piccolo, Stefano
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7316573
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7316573
Other Identifiers
ISSN
1476-1122
E-ISSN
1476-4660
DOI
10.1038/s41563-020-0615-x
