Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid ce...
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
About this item
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Author / Creator
Oh, Min-Hee , Sun, Im-Hong , Zhao, Liang , Leone, Robert D , Sun, Im-Meng , Xu, Wei , Collins, Samuel L , Tam, Ada J , Blosser, Richard L , Patel, Chirag H , Englert, Judson M , Arwood, Matthew L , Wen, Jiayu , Chan-Li, Yee , Tenora, Lukáš , Majer, Pavel , Rais, Rana , Slusher, Barbara S , Horton, Maureen R and Powell, Jonathan D
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
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More information
Scope and Contents
Contents
Myeloid cells comprise a major component of the tumor microenvironment (TME) that promotes tumor growth and immune evasion. By employing a small-molecule inhibitor of glutamine metabolism, not only were we able to inhibit tumor growth, but we markedly inhibited the generation and recruitment of myeloid-derived suppressor cells (MDSCs). Targeting tu...
Alternative Titles
Full title
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7324212
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7324212
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI131859
