Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
About this item
Full title
Author / Creator
Chakraborty, Abhishek A. , Laukka, Tuomas , Myllykoski, Matti , Ringel, Alison E. , Booker, Matthew A. , Tolstorukov, Michael Y. , Meng, Yuzhong Jeff , Meier, Samuel R. , Jennings, Rebecca B. , Creech, Amanda L. , Herbert, Zachary T. , McBrayer, Samuel K. , Olenchock, Benjamin A. , Jaffe, Jacob D. , Haigis, Marcia C. , Beroukhim, Rameen , Signoretti, Sabina , Koivunen, Peppi and Kaelin, William G.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Oxygen sensing is central to metazoan biology and has implications for human disease. Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG)-dependent dioxygenases (2-OGDDs), but they vary in their oxygen affinities and hence their ability to sense oxygen. The 2-OGDD histone demethylases control histone methylation. Hy...
Alternative Titles
Full title
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Authors, Artists and Contributors
Author / Creator
Laukka, Tuomas
Myllykoski, Matti
Ringel, Alison E.
Booker, Matthew A.
Tolstorukov, Michael Y.
Meng, Yuzhong Jeff
Meier, Samuel R.
Jennings, Rebecca B.
Creech, Amanda L.
Herbert, Zachary T.
McBrayer, Samuel K.
Olenchock, Benjamin A.
Jaffe, Jacob D.
Haigis, Marcia C.
Beroukhim, Rameen
Signoretti, Sabina
Koivunen, Peppi
Kaelin, William G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7336390
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7336390
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaw1026
