Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Mo...
Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights
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Full title
Author / Creator
Chiabotto, Giulia , Grignani, Giovanni , Todorovic, Maja , Martin, Valentina , Centomo, Maria Laura , Prola, Elisa , Giordano, Giorgia , Merlini, Alessandra , Miglio, Umberto , Berrino, Enrico , Napione, Lucia , Isella, Claudio , Capozzi, Federica , Basiricò, Marco , Marsero, Cristina , Gerardi, Ilaria , Venesio, Tiziana , Sangiolo, Dario , Aglietta, Massimo , D’Ambrosio, Lorenzo and Pignochino, Ymera
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Basel: MDPI AG
Subjects
More information
Scope and Contents
Contents
Receptor tyrosine kinases (RTKs) inhibitors’ activity in advanced osteosarcoma is significant but short-lived. To prevent or at least delay drug resistance, we explored a vertical inhibition by combining drugs acting at different levels of the RTK pathways (pazopanib + trametinib). We studied pazopanib + trametinib antitumor activity both in vitro...
Alternative Titles
Full title
Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights
Authors, Artists and Contributors
Author / Creator
Grignani, Giovanni
Todorovic, Maja
Martin, Valentina
Centomo, Maria Laura
Prola, Elisa
Giordano, Giorgia
Merlini, Alessandra
Miglio, Umberto
Berrino, Enrico
Napione, Lucia
Isella, Claudio
Capozzi, Federica
Basiricò, Marco
Marsero, Cristina
Gerardi, Ilaria
Venesio, Tiziana
Sangiolo, Dario
Aglietta, Massimo
D’Ambrosio, Lorenzo
Pignochino, Ymera
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7352822
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7352822
Other Identifiers
ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers12061519
