Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain’s striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression of HD are associated with the inflammatory respons...
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Full title
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7354937
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7354937
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2002144117
