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Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7354937

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

About this item

Full title

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (27), p.15989-15999

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain’s striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression of HD are associated with the inflammatory respons...

Alternative Titles

Full title

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7354937

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7354937

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2002144117

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