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Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7367492

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

About this item

Full title

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2020-03, Vol.579 (7798), p.297-302

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

After activation by an agonist, G-protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G-protein signalling and promotes receptor endocytosis
1
. Additionally, β-arrestin directly regulates many cell signalling pathways that can induce cellular responses distinct from that of G proteins
2
. In contrast...

Alternative Titles

Full title

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7367492

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7367492

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-020-1954-0

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