Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc
Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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After activation by an agonist, G-protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G-protein signalling and promotes receptor endocytosis
1
. Additionally, β-arrestin directly regulates many cell signalling pathways that can induce cellular responses distinct from that of G proteins
2
. In contrast...
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Full title
Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7367492
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7367492
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-1954-0