Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
About this item
Full title
Author / Creator
Park, Yong Hwan , Remmers, Elaine F. , Lee, Wonyong , Ombrello, Amanda K. , Chung, Lawton K. , Shilei, Zhao , Stone, Deborah L. , Ivanov, Maya I. , Loeven, Nicole A. , Barron, Karyl S. , Hoffmann, Patrycja , Nehrebecky, Michele , Akkaya-Ulum, Yeliz Z. , Sag, Erdal , Balci-Peynircioglu, Banu , Aksentijevich, Ivona , Gül, Ahmet , Rotimi, Charles N. , Chen, Hua , Bliska, James B. , Ozen, Seza , Kastner, Daniel L. , Shriner, Daniel and Chae, Jae Jin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in
MEFV
, which encodes pyrin, an inflammasome protein. Heterozygous carrier frequencies for multiple
MEFV
mutations are high in several Mediterranean populations, suggesting that they confer selecti...
Alternative Titles
Full title
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
Authors, Artists and Contributors
Author / Creator
Remmers, Elaine F.
Lee, Wonyong
Ombrello, Amanda K.
Chung, Lawton K.
Shilei, Zhao
Stone, Deborah L.
Ivanov, Maya I.
Loeven, Nicole A.
Barron, Karyl S.
Hoffmann, Patrycja
Nehrebecky, Michele
Akkaya-Ulum, Yeliz Z.
Sag, Erdal
Balci-Peynircioglu, Banu
Aksentijevich, Ivona
Gül, Ahmet
Rotimi, Charles N.
Chen, Hua
Bliska, James B.
Ozen, Seza
Kastner, Daniel L.
Shriner, Daniel
Chae, Jae Jin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381377
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381377
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0705-6
