Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex
Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Rubicon is a potent negative regulator of autophagy and a potential target for autophagy-inducing therapeutics. Rubicon-mediated inhibition of autophagy requires the interaction of the C-terminal Rubicon homology (RH) domain of Rubicon with Rab7–GTP. Here we report the 2.8-Å crystal structure of the Rubicon RH domain in complex with Rab7–GTP. Our s...
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Full title
Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7382272
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7382272
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2008030117
