Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart
Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart
About this item
Full title
Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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More information
Scope and Contents
Contents
The deleterious effects of diabetes in the heart are increasingly attributed to inflammatory signaling through the NLRP3 (NOD, LRR and PYD domains-containing protein 3) inflammasome. Thrombin antagonists reduce cardiac remodeling and dysfunction in diabetic mice, in part by suppressing fibrin-driven inflammation. The role of cellular thrombin recep...
Alternative Titles
Full title
Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7384378
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7384378
Other Identifiers
ISSN
0300-8428
E-ISSN
1435-1803
DOI
10.1007/s00395-019-0771-9
