Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia
Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Esophageal atresia (EA/TEF) is a common congenital abnormality present in 1 of 4000 births. Here we show that atretic esophagi lack Noggin (NOG) expression, resulting in immature esophagus that contains respiratory glands. Moreover, when using mouse esophageal organoid units (EOUs) or tracheal organoid units (TOUs) as a model of foregut development...
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Full title
Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7410075
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7410075
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI123597
