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Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7410075

Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

About this item

Full title

Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2020-08, Vol.130 (8), p.4396-4410

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Esophageal atresia (EA/TEF) is a common congenital abnormality present in 1 of 4000 births. Here we show that atretic esophagi lack Noggin (NOG) expression, resulting in immature esophagus that contains respiratory glands. Moreover, when using mouse esophageal organoid units (EOUs) or tracheal organoid units (TOUs) as a model of foregut development...

Alternative Titles

Full title

Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7410075

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7410075

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI123597

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