Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane
Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease
1
and antipsychotic drugs
2
. DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine
3
, leading to stimulation of G
i
and inhibition of adenylyl cyclase. Here we used cryo-electron microsc...
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Full title
Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7415663
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7415663
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2379-5
