Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming
Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Arginine auxotrophy due to the silencing of argininosuccinate synthetase 1 (ASS1) occurs in many carcinomas and in the majority of sarcomas. Arginine deiminase (ADI-PEG20) therapy exploits this metabolic vulnerability by depleting extracellular arginine, causing arginine starvation. ASS1-negative cells develop resistance to ADI-PEG20 through a meta...
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Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7438517
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7438517
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-02899-8
