Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured a...
Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured antibody mutants
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
"Antibody-breeding" approach potentially generates therapeutic/diagnostic antibody mutants with greater performance than native antibodies. Therein, antibody fragments (e.g., single-chain Fv fragments; scFvs) with a variety of mutations are displayed on bacteriophage to generate diverse phage-antibody libraries. Rare clones with improved functions...
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Full title
Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured antibody mutants
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7445280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7445280
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-71037-3
