Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
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Author / Creator
Corbett, Kizzmekia S , Flynn, Barbara , Foulds, Kathryn E , Francica, Joseph R , Boyoglu-Barnum, Seyhan , Werner, Anne P , Flach, Britta , O’Connell, Sarah , Bock, Kevin W , Minai, Mahnaz , Nagata, Bianca M , Andersen, Hanne , Martinez, David R , Noe, Amy T , Douek, Naomi , Donaldson, Mitzi M , Nji, Nadesh N , Alvarado, Gabriela S , Edwards, Darin K , Flebbe, Dillon R , Lamb, Evan , Doria-Rose, Nicole A , Lin, Bob C , Louder, Mark K , O’Dell, Sijy , Schmidt, Stephen D , Phung, Emily , Chang, Lauren A , Yap, Christina , Todd, John-Paul M , Pessaint, Laurent , Van Ry, Alex , Browne, Shanai , Greenhouse, Jack , Putman-Taylor, Tammy , Strasbaugh, Amanda , Campbell, Tracey-Ann , Cook, Anthony , Dodson, Alan , Steingrebe, Katelyn , Shi, Wei , Zhang, Yi , Abiona, Olubukola M , Wang, Lingshu , Pegu, Amarendra , Yang, Eun Sung , Leung, Kwanyee , Zhou, Tongqing , Teng, I-Ting , Widge, Alicia , Gordon, Ingelise , Novik, Laura , Gillespie, Rebecca A , Loomis, Rebecca J , Moliva, Juan I , Stewart-Jones, Guillaume , Himansu, Sunny , Kong, Wing-Pui , Nason, Martha C , Morabito, Kaitlyn M , Ruckwardt, Tracy J , Ledgerwood, Julie E , Gaudinski, Martin R , Kwong, Peter D , Mascola, John R , Carfi, Andrea , Lewis, Mark G , Baric, Ralph S , McDermott, Adrian , Moore, Ian N , Sullivan, Nancy J , Roederer, Mario , Seder, Robert A and Graham, Barney S
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Two injections of an mRNA-based vaccine encoding the SARS-CoV-2 spike protein elicited high levels of neutralizing antibody and Th1 CD4 T-cell responses in rhesus macaques. Two days after challenge of vaccinated animals with intranasal and intratracheal virus, viral replication was undetectable in bronchoalveolar-lavage fluid and nasal secretions.
Alternative Titles
Full title
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Authors, Artists and Contributors
Author / Creator
Flynn, Barbara
Foulds, Kathryn E
Francica, Joseph R
Boyoglu-Barnum, Seyhan
Werner, Anne P
Flach, Britta
O’Connell, Sarah
Bock, Kevin W
Minai, Mahnaz
Nagata, Bianca M
Andersen, Hanne
Martinez, David R
Noe, Amy T
Douek, Naomi
Donaldson, Mitzi M
Nji, Nadesh N
Alvarado, Gabriela S
Edwards, Darin K
Flebbe, Dillon R
Lamb, Evan
Doria-Rose, Nicole A
Lin, Bob C
Louder, Mark K
O’Dell, Sijy
Schmidt, Stephen D
Phung, Emily
Chang, Lauren A
Yap, Christina
Todd, John-Paul M
Pessaint, Laurent
Van Ry, Alex
Browne, Shanai
Greenhouse, Jack
Putman-Taylor, Tammy
Strasbaugh, Amanda
Campbell, Tracey-Ann
Cook, Anthony
Dodson, Alan
Steingrebe, Katelyn
Shi, Wei
Zhang, Yi
Abiona, Olubukola M
Wang, Lingshu
Pegu, Amarendra
Yang, Eun Sung
Leung, Kwanyee
Zhou, Tongqing
Teng, I-Ting
Widge, Alicia
Gordon, Ingelise
Novik, Laura
Gillespie, Rebecca A
Loomis, Rebecca J
Moliva, Juan I
Stewart-Jones, Guillaume
Himansu, Sunny
Kong, Wing-Pui
Nason, Martha C
Morabito, Kaitlyn M
Ruckwardt, Tracy J
Ledgerwood, Julie E
Gaudinski, Martin R
Kwong, Peter D
Mascola, John R
Carfi, Andrea
Lewis, Mark G
Baric, Ralph S
McDermott, Adrian
Moore, Ian N
Sullivan, Nancy J
Roederer, Mario
Seder, Robert A
Graham, Barney S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7449230
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7449230
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2024671
