Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Alzheimer's disease (AD) is characterized by plaques containing amyloid-β (Aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and Aβ, evidence suggests that microglia play an important role in AD pathogenesis. Rare variants in the microglia-expressed triggering receptor expressed on myeloid cells 2 (TREM2) g...
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Full title
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456230
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456230
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI138179
