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Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2...

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7476982

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

About this item

Full title

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Diabetologia, 2020-10, Vol.63 (10), p.2182-2193

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Aims/hypothesis
IRS2 is an important molecular switch that mediates insulin signalling in the liver.
IRS2
dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of
IRS2
in the liver of obese and type...

Alternative Titles

Full title

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7476982

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7476982

Other Identifiers

ISSN

0012-186X

E-ISSN

1432-0428

DOI

10.1007/s00125-020-05212-6

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