Structural basis of CD4 downregulation by HIV-1 Nef
Structural basis of CD4 downregulation by HIV-1 Nef
About this item
Full title
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote viral pathogenesis and is an attractive target for the development of novel therapeutics. A key function of Nef is to remove the CD4 receptor from the cell surface by hijacking clathrin- and adaptor protein complex 2 (AP2)-dependent endocytosis. However, exactly how...
Alternative Titles
Full title
Structural basis of CD4 downregulation by HIV-1 Nef
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7483821
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7483821
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-0463-z
