TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multi...
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
About this item
Full title
Author / Creator
Cignarella, Francesca , Filipello, Fabia , Bollman, Bryan , Cantoni, Claudia , Locca, Alberto , Mikesell, Robert , Manis, Melissa , Ibrahim, Adiljan , Deng, Li , Benitez, Bruno A. , Cruchaga, Carlos , Licastro, Danilo , Mihindukulasuriya, Kathie , Harari, Oscar , Buckland, Michael , Holtzman, David M. , Rosenthal, Arnon , Schwabe, Tina , Tassi, Ilaria and Piccio, Laura
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2 is expressed by microglia and promotes microglial survival, pro...
Alternative Titles
Full title
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
Authors, Artists and Contributors
Author / Creator
Filipello, Fabia
Bollman, Bryan
Cantoni, Claudia
Locca, Alberto
Mikesell, Robert
Manis, Melissa
Ibrahim, Adiljan
Deng, Li
Benitez, Bruno A.
Cruchaga, Carlos
Licastro, Danilo
Mihindukulasuriya, Kathie
Harari, Oscar
Buckland, Michael
Holtzman, David M.
Rosenthal, Arnon
Schwabe, Tina
Tassi, Ilaria
Piccio, Laura
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7498497
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7498497
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-020-02193-z
