CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The RAG endonuclease initiates
Igh
locus V(D)J recombination in progenitor (pro)-B cells
1
. Upon binding a recombination centre-based J
H
, RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate Ds and assemble a DJ
H
-based recombination centre
2
. CTCF looping factor-bound elemen...
Alternative Titles
Full title
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7554077
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7554077
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2578-0
