Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy
Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy
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Author / Creator
Xue, Jiaming , Patergnani, Simone , Giorgi, Carlotta , Suarez, Joelle , Goto, Keisuke , Bononi, Angela , Tanji, Mika , Novelli, Flavia , Pastorino, Sandra , Xu, Ronghui , Caroccia, Natascia , Dogan, A. Umran , Pass, Harvey I. , Tognon, Mauro , Pinton, Paolo , Gaudino, Giovanni , Mak, Tak W. , Carbone, Michele and Yang, Haining
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as exposure to asbestos induces HM death. However, some asbestos-exposed HM escape cell death, accumulate DNA damage, and may become transformed. We previously demonstrated that, upon...
Alternative Titles
Full title
Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7568322
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7568322
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2007622117
