A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma
About this item
Full title
Author / Creator
Harb, Hani , Stephen-Victor, Emmanuel , Crestani, Elena , Benamar, Mehdi , Massoud, Amir , Cui, Ye , Charbonnier, Louis-Marie , Arbag, Sena , Baris, Safa , Cunnigham, Amparito , Leyva-Castillo, Juan Manuel , Geha, Raif S. , Mousavi, Amirhosein J. , Guennewig, Boris , Schmitz-Abe, Klaus , Sioutas, Constantinos , Phipatanakul, Wanda and Chatila, Talal A.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (T
reg
) cells is necessary for allergens and particulate matter pollutants to promote airway inflammation. Notch4...
Alternative Titles
Full title
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma
Authors, Artists and Contributors
Author / Creator
Stephen-Victor, Emmanuel
Crestani, Elena
Benamar, Mehdi
Massoud, Amir
Cui, Ye
Charbonnier, Louis-Marie
Arbag, Sena
Baris, Safa
Cunnigham, Amparito
Leyva-Castillo, Juan Manuel
Geha, Raif S.
Mousavi, Amirhosein J.
Guennewig, Boris
Schmitz-Abe, Klaus
Sioutas, Constantinos
Phipatanakul, Wanda
Chatila, Talal A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7578174
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7578174
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0777-3
