SARS-CoV-2 evolution during treatment of chronic infection
SARS-CoV-2 evolution during treatment of chronic infection
About this item
Full title
Author / Creator
Kemp, Steven A. , Collier, Dami A. , Datir, Rawlings P. , Ferreira, Isabella A. T. M. , Gayed, Salma , Jahun, Aminu , Hosmillo, Myra , Rees-Spear, Chloe , Mlcochova, Petra , Lumb, Ines Ushiro , Roberts, David J. , Chandra, Anita , Temperton, Nigel , Sharrocks, Katherine , Blane, Elizabeth , Modis, Yorgo , Leigh, Kendra E. , Briggs, John A. G. , van Gils, Marit J. , Smith, Kenneth G. C. , Bradley, John R. , Smith, Chris , Doffinger, Rainer , Ceron-Gutierrez, Lourdes , Barcenas-Morales, Gabriela , Pollock, David D. , Goldstein, Richard A. , Smielewska, Anna , Skittrall, Jordan P. , Gouliouris, Theodore , Goodfellow, Ian G. , Gkrania-Klotsas, Effrossyni , Illingworth, Christopher J. R. , McCoy, Laura E. , Gupta, Ravindra K. , ANPC & Centre for Molecular Medicine & Innovative Therapeutics , Leadership & supervision, sequencing & analysis and software & analysis tools , Metadata curation, samples & logistics and sequencing & analysis , Funding acquisition, metadata curation, samples & logistics, sequencing & analysis, software & analysis tools and visualization , Metadata curation, project administration, samples & logistics, sequencing & analysis and software & analysis tools , Samples & logistics , Leadership & supervision, metadata curation, samples & logistics and visualization , Sequencing & analysis , Funding acquisition, leadership & supervision, metadata curation and samples & logistics , Project administration and samples & logistics , Metadata curation, sequencing & analysis, software & analysis tools and visualization , Leadership & supervision, metadata curation, sequencing & analysis and software & analysis tools , Funding acquisition, leadership & supervision and metadata curatio , Software & analysis tools , Samples & logistics, sequencing & analysis and software & analysis tools , Leadership & supervision, metadata curation, samples & logistics and software & analysis tools , Project administration , Funding acquisition, leadership & supervision, metadata curation, project administration and samples & logistics , Metadata curation, project administration, samples & logistics and sequencing & analysis , Funding acquisition and leadership & supervision , Samples & logistics and Sequencing & analysis , Project administration, samples & logistics and visualization , NIHR BioResource , Leadership & supervision, metadata curation, project administration, samples & logistics and visualization , Funding acquisition, leadership & supervision and sequencing & analysis , Funding acquisition, leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis and software & analysis tools , Leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis, software & analysis tools and visualization , Leadership & supervision, project administration and samples & logistics , Leadership & supervision , Samples & logistics and software & analysis tools , Metadata curation, project administration, samples & logistics, sequencing & analysis and visualization , Leadership & supervision, metadata curation, project administration and samples & logistics , Leadership & supervision and metadata curation , Leadership & supervision, samples & logistics and sequencing & analysis , Cambridge & Peterborough Foundation Trust , Project administration, samples & logistics and software & analysis tools , Project administration, sequencing & analysis, software & analysis tools and visualization , Leadership & supervision and project administration , Funding acquisition, samples & logistics, sequencing & analysis, software & analysis tools and visualization , Metadata curation, project administration, sequencing & analysis and software & analysis tools , Funding acquisition, leadership & supervision, project administration, samples & logistics and sequencing & analysis , Sequencing & analysis, software & analysis tools and visualization , Metadata curation and sequencing & analysis , Addenbrooke’s Hospital ICU , Leadership & supervision, project administration and sequencing & analysis , Principal investigators , Software & analysis tools and visualization , Leadership & supervision, project administration, samples & logistics and sequencing & analysis , Leadership & supervision, sequencing & analysis, software & analysis tools and visualization , Funding acquisition, leadership & supervision, metadata curation, samples & logistics and sequencing & analysis , Funding acquisition, leadership & supervision, project administration and samples & logistics , Sequencing & analysis and software & analysis tools , Metadata curation, samples & logistics, sequencing & analysis and visualization , Metadata curation, project administration and sequencing & analysis , Leadership & supervision, sequencing & analysis and visualization , Leadership & supervision and samples & logistics , Funding acquisition, leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis, software & analysis tools and visualization , Leadership & supervision, metadata curation, project administration, sequencing & analysis and software & analysis tools , Leadership & supervision, metadata curation, samples & logistics and sequencing & analysis , CRF & volunteer research nurses , The COVID-19 Genomics UK (COG-UK) Consortium , Project administration and sequencing & analysis , Clinical data collection , Leadership & supervision, metadata curation and sequencing & analysis , Royal Papworth Hospital ICU , Metadata curation, sequencing & analysis and visualization , Leadership & supervision and sequencing & analysis , Leadership & supervision and visualization , The CITIID-NIHR BioResource COVID-19 Collaboration , Sample processing & data acquisition , Sample logistics , Metadata curation , Funding acquisition, leadership & supervision, sequencing & analysis, software & analysis tools and visualization , Metadata curation, project administration and samples & logistics , Leadership & supervision, metadata curation, project administration, samples & logistics and sequencing & analysis , Funding acquisition, leadership & supervision and project administration , Visualization , Project administration, samples & logistics and sequencing & analysis , Project administration and software & analysis tools , Metadata curation and samples & logistics , Metadata curation and software & analysis tools , Funding acquisition and project administration , Metadata curation, samples & logistics and visualization , Metadata curation, sequencing & analysis and software & analysis tools , COVID-19 Genomics UK (COG-UK) Consortium and CITIID-NIHR BioResource COVID-19 Collaboration
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein
1
and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppres...
Alternative Titles
Full title
SARS-CoV-2 evolution during treatment of chronic infection
Authors, Artists and Contributors
Author / Creator
Collier, Dami A.
Datir, Rawlings P.
Ferreira, Isabella A. T. M.
Gayed, Salma
Jahun, Aminu
Hosmillo, Myra
Rees-Spear, Chloe
Mlcochova, Petra
Lumb, Ines Ushiro
Roberts, David J.
Chandra, Anita
Temperton, Nigel
Sharrocks, Katherine
Blane, Elizabeth
Modis, Yorgo
Leigh, Kendra E.
Briggs, John A. G.
van Gils, Marit J.
Smith, Kenneth G. C.
Bradley, John R.
Smith, Chris
Doffinger, Rainer
Ceron-Gutierrez, Lourdes
Barcenas-Morales, Gabriela
Pollock, David D.
Goldstein, Richard A.
Smielewska, Anna
Skittrall, Jordan P.
Gouliouris, Theodore
Goodfellow, Ian G.
Gkrania-Klotsas, Effrossyni
Illingworth, Christopher J. R.
McCoy, Laura E.
Gupta, Ravindra K.
ANPC & Centre for Molecular Medicine & Innovative Therapeutics
Leadership & supervision, sequencing & analysis and software & analysis tools
Metadata curation, samples & logistics and sequencing & analysis
Funding acquisition, metadata curation, samples & logistics, sequencing & analysis, software & analysis tools and visualization
Metadata curation, project administration, samples & logistics, sequencing & analysis and software & analysis tools
Samples & logistics
Leadership & supervision, metadata curation, samples & logistics and visualization
Sequencing & analysis
Funding acquisition, leadership & supervision, metadata curation and samples & logistics
Project administration and samples & logistics
Metadata curation, sequencing & analysis, software & analysis tools and visualization
Leadership & supervision, metadata curation, sequencing & analysis and software & analysis tools
Funding acquisition, leadership & supervision and metadata curatio
Software & analysis tools
Samples & logistics, sequencing & analysis and software & analysis tools
Leadership & supervision, metadata curation, samples & logistics and software & analysis tools
Project administration
Funding acquisition, leadership & supervision, metadata curation, project administration and samples & logistics
Metadata curation, project administration, samples & logistics and sequencing & analysis
Funding acquisition and leadership & supervision
Samples & logistics and Sequencing & analysis
Project administration, samples & logistics and visualization
NIHR BioResource
Leadership & supervision, metadata curation, project administration, samples & logistics and visualization
Funding acquisition, leadership & supervision and sequencing & analysis
Funding acquisition, leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis and software & analysis tools
Leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis, software & analysis tools and visualization
Leadership & supervision, project administration and samples & logistics
Leadership & supervision
Samples & logistics and software & analysis tools
Metadata curation, project administration, samples & logistics, sequencing & analysis and visualization
Leadership & supervision, metadata curation, project administration and samples & logistics
Leadership & supervision and metadata curation
Leadership & supervision, samples & logistics and sequencing & analysis
Cambridge & Peterborough Foundation Trust
Project administration, samples & logistics and software & analysis tools
Project administration, sequencing & analysis, software & analysis tools and visualization
Leadership & supervision and project administration
Funding acquisition, samples & logistics, sequencing & analysis, software & analysis tools and visualization
Metadata curation, project administration, sequencing & analysis and software & analysis tools
Funding acquisition, leadership & supervision, project administration, samples & logistics and sequencing & analysis
Sequencing & analysis, software & analysis tools and visualization
Metadata curation and sequencing & analysis
Addenbrooke’s Hospital ICU
Leadership & supervision, project administration and sequencing & analysis
Principal investigators
Software & analysis tools and visualization
Leadership & supervision, project administration, samples & logistics and sequencing & analysis
Leadership & supervision, sequencing & analysis, software & analysis tools and visualization
Funding acquisition, leadership & supervision, metadata curation, samples & logistics and sequencing & analysis
Funding acquisition, leadership & supervision, project administration and samples & logistics
Sequencing & analysis and software & analysis tools
Metadata curation, samples & logistics, sequencing & analysis and visualization
Metadata curation, project administration and sequencing & analysis
Leadership & supervision, sequencing & analysis and visualization
Leadership & supervision and samples & logistics
Funding acquisition, leadership & supervision, metadata curation, project administration, samples & logistics, sequencing & analysis, software & analysis tools and visualization
Leadership & supervision, metadata curation, project administration, sequencing & analysis and software & analysis tools
Leadership & supervision, metadata curation, samples & logistics and sequencing & analysis
CRF & volunteer research nurses
The COVID-19 Genomics UK (COG-UK) Consortium
Project administration and sequencing & analysis
Clinical data collection
Leadership & supervision, metadata curation and sequencing & analysis
Royal Papworth Hospital ICU
Metadata curation, sequencing & analysis and visualization
Leadership & supervision and sequencing & analysis
Leadership & supervision and visualization
The CITIID-NIHR BioResource COVID-19 Collaboration
Sample processing & data acquisition
Sample logistics
Metadata curation
Funding acquisition, leadership & supervision, sequencing & analysis, software & analysis tools and visualization
Metadata curation, project administration and samples & logistics
Leadership & supervision, metadata curation, project administration, samples & logistics and sequencing & analysis
Funding acquisition, leadership & supervision and project administration
Visualization
Project administration, samples & logistics and sequencing & analysis
Project administration and software & analysis tools
Metadata curation and samples & logistics
Metadata curation and software & analysis tools
Funding acquisition and project administration
Metadata curation, samples & logistics and visualization
Metadata curation, sequencing & analysis and software & analysis tools
COVID-19 Genomics UK (COG-UK) Consortium
CITIID-NIHR BioResource COVID-19 Collaboration
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610568
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610568
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03291-y
