Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of...
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
About this item
Full title
Author / Creator
Ponsioen, Bas , Post, Jasmin B. , Buissant des Amorie, Julian R. , Laskaris, Dimitrios , van Ineveld, Ravian L. , Kersten, Simone , Bertotti, Andrea , Sassi, Francesco , Sipieter, François , Cappe, Benjamin , Mertens, Sander , Verlaan-Klink, Ingrid , Boj, Sylvia F. , Vries, Rob G. J. , Rehmann, Holger , Vandenabeele, Peter , Riquet, Franck B. , Trusolino, Livio , Bos, Johannes L. and Snippert, Hugo J. G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in
KRAS
and
BRAF
mutant colorectal cancer (CRC) has proven clinically unsuccessful, but promising results have been obtained with combination therapies including epidermal growth factor receptor...
Alternative Titles
Full title
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Authors, Artists and Contributors
Author / Creator
Post, Jasmin B.
Buissant des Amorie, Julian R.
Laskaris, Dimitrios
van Ineveld, Ravian L.
Kersten, Simone
Bertotti, Andrea
Sassi, Francesco
Sipieter, François
Cappe, Benjamin
Mertens, Sander
Verlaan-Klink, Ingrid
Boj, Sylvia F.
Vries, Rob G. J.
Rehmann, Holger
Vandenabeele, Peter
Riquet, Franck B.
Trusolino, Livio
Bos, Johannes L.
Snippert, Hugo J. G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610573
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610573
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00654-5
