A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates...
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals
About this item
Full title
Author / Creator
Demetriou, Philippos , Abu-Shah, Enas , Valvo, Salvatore , McCuaig, Sarah , Mayya, Viveka , Kvalvaag, Audun , Starkey, Thomas , Korobchevskaya, Kseniya , Lee, Lennard Y. W. , Friedrich, Matthias , Mann, Elizabeth , Kutuzov, Mikhail A. , Morotti, Matteo , Wietek, Nina , Rada, Heather , Yusuf, Shamsideen , Afrose, Jehan , Siokis, Anastasios , Meyer-Hermann, Michael , Ahmed, Ahmed Ashour , Depoil, David , Dustin, Michael L. and Oxford IBD Cohort Investigators
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC, in a pattern we refer to as a ‘CD2 corolla’. The corolla captured engaged CD28, ICOS, CD226 and SLAM-F1 co-stimulators. The coro...
Alternative Titles
Full title
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals
Authors, Artists and Contributors
Author / Creator
Abu-Shah, Enas
Valvo, Salvatore
McCuaig, Sarah
Mayya, Viveka
Kvalvaag, Audun
Starkey, Thomas
Korobchevskaya, Kseniya
Lee, Lennard Y. W.
Friedrich, Matthias
Mann, Elizabeth
Kutuzov, Mikhail A.
Morotti, Matteo
Wietek, Nina
Rada, Heather
Yusuf, Shamsideen
Afrose, Jehan
Siokis, Anastasios
Meyer-Hermann, Michael
Ahmed, Ahmed Ashour
Depoil, David
Dustin, Michael L.
Oxford IBD Cohort Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611174
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611174
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0770-x
