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Structure of pathological TDP-43 filaments from ALS with FTLD

Structure of pathological TDP-43 filaments from ALS with FTLD

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7612255

Structure of pathological TDP-43 filaments from ALS with FTLD

About this item

Full title

Structure of pathological TDP-43 filaments from ALS with FTLD

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2022-01, Vol.601 (7891), p.139-143

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The abnormal aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in neurons and glia is the defining pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and multiple forms of frontotemporal lobar degeneration (FTLD)
1
,
2
. It is also common in other diseases, including Alzheimer’s and Parkinson...

Alternative Titles

Full title

Structure of pathological TDP-43 filaments from ALS with FTLD

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7612255

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7612255

Other Identifiers

ISSN

0028-0836,1476-4687

E-ISSN

1476-4687

DOI

10.1038/s41586-021-04199-3

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