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New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive...

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7612594

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

About this item

Full title

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Publisher

New York: Nature Publishing Group US

Journal title

Nature neuroscience, 2022-04, Vol.25 (4), p.415-420

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes ge...

Alternative Titles

Full title

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7612594

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7612594

Other Identifiers

ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/s41593-021-01009-x

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