Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
About this item
Full title
Author / Creator
Mancuso, Renzo , Van Den Daele, Johanna , Fattorelli, Nicola , Wolfs, Leen , Balusu, Sriram , Burton, Oliver , Liston, Adrian , Sierksma, Annerieke , Fourne, Yannick , Poovathingal, Suresh , Arranz-Mendiguren, Amaia , Sala Frigerio, Carlo , Claes, Christel , Serneels, Lutgarde , Theys, Tom , Perry, V. Hugh , Verfaillie, Catherine , Fiers, Mark and De Strooper, Bart
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Although genetics highlights the role of microglia in Alzheimer’s disease, one-third of putative Alzheimer’s disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression...
Alternative Titles
Full title
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Authors, Artists and Contributors
Author / Creator
Van Den Daele, Johanna
Fattorelli, Nicola
Wolfs, Leen
Balusu, Sriram
Burton, Oliver
Liston, Adrian
Sierksma, Annerieke
Fourne, Yannick
Poovathingal, Suresh
Arranz-Mendiguren, Amaia
Sala Frigerio, Carlo
Claes, Christel
Serneels, Lutgarde
Theys, Tom
Perry, V. Hugh
Verfaillie, Catherine
Fiers, Mark
De Strooper, Bart
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7616913
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7616913
Other Identifiers
ISSN
1097-6256,1546-1726
E-ISSN
1546-1726
DOI
10.1038/s41593-019-0525-x
