Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport sy...
Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
X-linked Alport syndrome (XLAS) is a progressive kidney disease caused by genetic abnormalities of
COL4A5.
Lack of collagen IV α5 chain staining and “basket-weave” by electron microscopy (EM) in glomerular basement membrane (GBM) are its typical pathology. However, the causal relationship between GBM defects and progressive nephropathy is unk...
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Full title
Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7642296
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7642296
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-76068-4
