PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitat...
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
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Author / Creator
Hou, Junwei , Zhao, Rongce , Xia, Weiya , Chang, Chiung-Wen , You, Yun , Hsu, Jung-Mao , Nie, Lei , Chen, Yeh , Wang, Yu-Chuan , Liu, Chunxiao , Wang, Wei-Jan , Wu, Yun , Ke, Baozhen , Hsu, Jennifer L. , Huang, Kebin , Ye, Zu , Yang, Yi , Xia, Xianghou , Li, Yintao , Li, Chia-Wei , Shao, Bin , Tainer, John A. and Hung, Mien-Chie
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with unknown function. Here we show that PD-L1 switches TNFα-induced apoptosis to pyroptosis in cancer cells, resulting in tumour necrosis. Under hypoxia, p-Stat3 physically inte...
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Full title
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7653546
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7653546
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-020-0575-z
