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First-in-class humanized FSH blocking antibody targets bone and fat

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First-in-class humanized FSH blocking antibody targets bone and fat

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7682550

First-in-class humanized FSH blocking antibody targets bone and fat

About this item

Full title

First-in-class humanized FSH blocking antibody targets bone and fat

Author / Creator

Gera, Sakshi , Sant, Damini , Haider, Shozeb , Korkmaz, Funda , Kuo, Tan-Chun , Mathew, Mehr , Perez-Pena, Helena , Xie, Honglin , Chend, Hao , Batista, Rogerio , Ma, Kejun , Cheng, Zhen , Hadelia, Elina , Robinson, Cemre , Macdonald, Anne , Miyashita, Sari , Williams, Anthony , Jebian, Gregory , Miyashita, Hirotaka , Gumerova, Anisa , Ievleva, Kseniia , Smith, Pinar , He, Jiahuan , Ryu, Vitaly , DeMambro, Victoria , Quinn, Matthew A. , Meseck, Marcia , Kim, Se-Min , Kumar, T. Rajendra , Iqbal, Jameel , New, Maria I. , Lizneva, Daria , Rosen, Clifford J. , Hsueh, Aaron J. , Yuen, Tony and Zaidi, Mone

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (46), p.28971-28979

Language

English

Formats

Articles

Publication information

Publisher

United States: National Academy of Sciences

Subjects

More information

Scope and Contents

Contents

Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, structure, and function of a first-in-class, fully huma...

Alternative Titles

Full title

First-in-class humanized FSH blocking antibody targets bone and fat

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7682550

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7682550

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2014588117

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