Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity. Here we report a 2.1-Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy. In lipid bilayers that mimic the endoplasmic reticulum–Gol...
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Full title
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7718435
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7718435
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-00536-8
